New insight on crescentic glomerulonephritis

New insight on crescentic glomerulonephritis

4þ haematuria, but urinary sediments showed few red blood cells (1-2-1/high-power fields). His renal function recovered concomitantly with improvement of haemolytic anaemia; thus, haemolysis might also have contributed to the development of his renal dysfunction. Indeed, haemolysisrelated renal dysfunction has occurred in patients with HCV infection [1]. Our patient showed cryoglobulinaemia, bu...

Experimental crescentic glomerulonephritis: a new bicongenic rat model

Crescentic glomerulonephritis (CRGN) is a major cause of human kidney failure, but the underlying mechanisms are not fully understood. Wistar Kyoto (WKY) rats are uniquely susceptible to CRGN following injection of nephrotoxic serum, whereas Lewis (LEW) rats are resistant. Our previous genetic studies of nephrotoxic nephritis (NTN), a form of CRGN induced by nephrotoxic serum, identified Fcgr3 ...

T cells in crescentic glomerulonephritis.

Crescent formation in glomerulonephritis (GN) is a manifestation of severe glomerular injury that usually results in a poor clinical outcome. In humans, crescentic GN is frequently associated with evidence of either systemic or organ-specific autoimmunity. T cells play a major role in initiation of adaptive immune responses that lead to crescentic injury. In experimental models of crescentic GN...

Crescentic glomerulonephritis and centrocytic lymphoma.

Scleroderma with crescentic glomerulonephritis: a case report

INTRODUCTION Systemic sclerosis or scleroderma is an autoimmune rheumatic disease characterized by organ-based fibrosis. Renal involvement in scleroderma occurs mainly in the form of scleroderma renal crisis, affecting 5 to 10% of patients. It remains one of the most important and immediately life-threatening complications of scleroderma, but the prognosis improves considerably after treatment ...